Some sarms, such as gw501516 and sr9009, we believe do not inhibit endogenous testosterone secretion and therefore do not need to use SERM clomiphene or enclomiphene. Other sarms, such as mk2866 and rad 140, mimic the mode of action of testosterone and inhibit endogenous testosterone production, requiring the use of SERM. Regarding when to use SERM, is it at the beginning of the cycle, in the middle of the cycle, near the end of the cycle junction, or after the cycle (PCT)? Different people have different opinions, and we have summarized these opinions.
We have talked a lot about the use of SERM after cycle (PCT), and if SERM is used during the period, sarms users prefer to use enclomiphene rather than clomiphene. In fact, in pct, they also use enclo. Today, we will not talk about the difference between enclo and clomid, but about which phase in the cycle they use serm.
Use SERM enclomiphene on the first day
A large percentage of bodybuilders prefer to use a SERM enclo on the first day of the cycle. They believe that sarms (mentioned here are inhibitory Sarms such as rad140, not non-inhibitory Sarms such as gw501516) mimic the action of testosterone, and it will start to exert inhibitory effects from the moment it enters the body, so you need to use serm enclo to maintain your endogenous testosterone secretion levels.
In terms of inhibition, the idea is correct. Doing so keeps endogenous testosterone levels uninhibited and at normal levels.
Start using serm enclomiphene in the second week of the cycle
Bodybuilders, who hold this view, believe that with stronger sarms like RAD140, which have a very high inhibitory effect, there is a possibility of more severe testosterone inhibition or shutdown in the fourth week of the cycle, so it is necessary to start enclo earlier, preferably no later than the second week of the cycle.
Many people agree with this view, because for safety reasons, no one wants to have their testosterone levels severely suppressed or shut down. There is a dosing issue involved, rad140 is given in doses of 10-30mg ED. Low doses of rad140 can be effective, and rad140 is used at low doses without severe testosterone suppression.
The serm enclo starts on the fourth week of the cycle
Some sarms start in the fourth week, with noticeable changes in muscle mass to strength levels, which is when hormone levels in the body are thought to be highest, after which total testosterone levels begin to decline (inhibition begins to show). At this time, SERM enclo is used to block the negative feedback effect of estrogen on HPTA, ensure the continuous release of testosterone, maintain testicular function, and maintain the testosterone level after the cycle.
Use a SERM enclo after the end of the cycle (PCT)
Post-cycle therapy (PCT) is the official procedure for the sarms or AAS cycle. Compa...

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Rather than directly using exogenous testosterone replacement therapy (TRT), some men diagnosed with low testosterone levels prefer to try Enclomiphene to help promote the production of endogenous testosterone, thereby increasing their testosterone levels. Compared to TRT, enclomiphene <https://www.astersteroids.com/enclomifene-vs-clomifene-in-pct-is-enclo-works-better/> brings low libido side effects, so some men have to give up using it.
How does Enclomiphene increase endogenous testosterone levels
Enclomiphene is a selective estrogen receptor modulator, acting in the same way as Clomiphene. By antagonizing the effect of estrogen in the pituitary gland, Enclomiphene makes HPTA (hypothalamic-pituitary-testicular axis) continue to act positively and stimulate the production of testosterone by testis, thereby increasing the level of autocrine testosterone.
Enclomiphene cause low libido
A 40-year-old man who normally felt fine had no obvious symptoms of low testosterone. Influenced by his friend, he also went to test his own testosterone levels, which showed that his Total T was 380 ng/dl and his Free T is 7.3 ng/dl. Tests showed he had low testosterone and he was given 12.5mg of Enclomiphene a day. A month later, his total T had risen to 798ng/dl and his Free T had also increased to 16.4 ng/dl.
Enclomiphene doubled his testosterone levels, however, in addition to the benefits of high testosterone levels, his libido was greatly suppressed.
Another 50-year-old male user takes Enclo at a dose of 25mg three times a week to treat low testosterone levels. Enclo does help raise testosterone levels, but sex drive is rarely experienced while Enclo is being used, and can return when the drug is discontinued.
Another man who used 9.37mg of Enclo a day to treat low testosterone levels also experienced low libido (but still can get hard).
Why does Enclomiphene inhibit libido compared to Clomid?
Clomid is equivalent to 38% Zuclomifene (estrogen receptor agonist) and 62% enclomifene (estrogen receptor antagonist). Therefore, Enclomiphene is used to reduce the side effects of estrogen. There are many factors that affect libido, and estrogen levels happen to be one of them.
Enclomiphene dosage
The usual Enclomiphene dose is 12.5mg or 25mg per day. However, the recommended dose for most people who have used Enclo is 6.25mg ED. enclomiphene, at a low dose, maintains the function of estrogen without affecting libido. If the libido problem does not improve, the dose may be changed to EOD, or E3D.