Reduce belly fat
Tesamorelin can improve fat distribution in patients with lipodystrophy and promote the reduction of abdominal fat. In HIV patients with abdominal fat accumulation, daily subcutaneous injection of 2mg Tesamorelin treatment resulted in a sustained reduction in visceral fat.
In 2010, the FDA approved the use of Tesamorelin to reduce excess abdominal fat in HIV-infected malnourished patients, and experiments showed that the average abdominal fat was reduced by about 18% after 6 months of treatment with Tesamorelin.
Increase muscle mass
Tesamorelin increases skeletal muscle density (reduces fat) and skeletal muscle area, supporting an overall improvement in muscle mass.
In the trial, a significant increase in total muscle density and muscle area in all four trunk muscle groups (rectus abdominis, anterolateral abdominis, psoas major, and paravertebral muscles) was observed by computed tomography (CT) after Tesamorelin treatment.
Improve liver health
For both male and female patients with liver fat accumulation, treatment with Tesamorelin for 12 months resulted in a significant reduction in liver fat. In treatment, Tesamorelin causes a significant increase in creatine phosphate, which effectively protects the liver from hypoxia and impaired blood flow.
Improve blood lipid profile and reduce the risk of cardiovascular disease
Tesamorelin has beneficial effects on triglyceride, total cholesterol, low density lipoprotein and high density lipoprotein. Tesamorelin is used to reduce visceral fat, improve blood lipid and blood sugar status, and reduce the risk of cardiovascular diseases.
Improve cognitive function
Tesamorelin, as an analogue of GHRH, has a significant effect on brain function. For people with age-related memory problems and those with chronic progressive mental decline, Tesamorelin use improves executive function, verbal and visual memory, thinking skills, and neurocognitive abilities.
Treatment of nerve injury
Nerve damage can lead to impaired motor and sensory function in the affected area, and research shows that the use of Tesamorelin can speed up the healing of damaged nerves.

Why bodybuilders use Tesamorelin? In fact, no drugs have been approved for bodybuilding, any compound used in bodybuilding is based on its anabolic effects to help build muscle, lose fat or increase energy levels, etc., and before each compound becomes popular among bodybuilders, Have been verified by numerous bodybuilders in actual use.
Bodybuilder uses Tesamorelin based on three main points. First, it is FDA approved, second, it is derived from natural hormones produced by the body, and finally, it stimulates the production of GH and IGF-1.
Tesamorelin is an FDA-approved drug
The FDA approved the use of Tesamorelin to reduce abdominal fat. In the course of HIV patients receiving drug treatment, the way of fat distribution in the body changes, resulting in a large amount of fat accumulation in the abdomen, causing physical deformities and reducing the quality of life of patients.
The safety and effectiveness of a new drug has been verified from discovery through clinical trials until it is approved by the FDA, so bodybuilders' use of Tesamorelin is first and foremost assured of safety.
Tesamorelin is derived from GHRH
Growth hormone-releasing hormone (GHRH) is a peptide hormone composed of 44 amino acids produced primarily in the hypothalamus. Tesamorelin is a compound based on all 44 amino acid sequences of GHRH with the addition of modified compounds at its N-terminal. Therefore, Tesamorelin is derived from hormones naturally produced by the human body. By modifying the body's naturally produced hormones to make them more stable and effective, they can be synthesized and used to treat the corresponding diseases.
Tesamorelin stimulates the production of GH and IGF-1
Tesamorelin is derived from GHRH, and once in the body, it binds to GHRH receptors and stimulates the release of growth hormone (GH) and IGF-1.
GH(HGH) and IGF-1(IGF-1 LR3) are two anabolic peptides commonly used by bodybuilders to improve the body's metabolism, improve muscle growth, improve fat distribution, and help bodybuilders provide energy. build muscle and reduce body fat. HGH and IGF-1 LR3 are two very popular anabolic peptides, Tesamorelin acting upstream of GH, promoting GH release without the side effects of HGH excess to bodybuilders.

With the growth of age and the gradual decline of metabolism, obesity problems gradually become more prominent. Fat loss is a problem that is related to almost all middle-aged people, among which, how to reduce belly fat is another difficult problem in fat loss. Today, we're going to talk about how Tesamorelin can reduce belly fat.
Fat and belly fat
Fat is a way for humans to store food in order to conserve energy. There are many ways to provide energy to the body, mainly sugar and fat. Fat is the most energy-dense, releasing much more energy for the same weight of fat than when sugar is broken down.
When food is scarce, fat storage energy is beneficial to the health of the body, however, in today's material abundance, when the intake of energy is much more than the energy consumed by the body, excess heat continues to accumulate in the body, fat storage gradually increases, forming obesity.
Abdominal fat is the most dangerous type of fat because when it grows in the abdominal area, it surrounds the internal organs. Large amounts of belly fat can put people at risk for a variety of health problems, including heart disease, diabetes, liver problems, and an increased risk of sudden death.
Why use Tesamorelin to reduce belly fat?
Tesamorelin is an FDA-approved treatment for reducing excess abdominal fat in HIV-infected patients with lipodystrophy associated with antiviral therapy. Tesamorelin has also been evaluated as a treatment for insulin resistance, obesity, and non-alcoholic fatty liver disease.
How does Tesamorelin reduce belly fat?
Tesamorelin is a compound modified on the N-terminal of all 44 amino acid sequences of GHRH(growth hormone releasing hormone), which is more effective and stable than GHRH. After Tesamorelin is used, it enters the body and binds to GHRH receptors, stimulating the release of growth hormone (GH). Increased GH levels boost metabolism and improve muscle growth, which helps burn more calories and reduce fat in the body. Tesamorelin also helps increase insulin growth factor (IGF-1), which further stimulates weight loss. Therefore, Tesamorelin helps to reduce visceral fat and improve abdominal appearance, size, and waist circumference.

The benefits of Tesamorelin
Tesamorelin plays a similar role to GHRH by binding to GHRH receptors, stimulating the synthesis and release of endogenous GH. The released GH boosts metabolism and improves muscle growth, helping to burn more calories and reduce fat in the body. Tesamorelin also helps to increase IGF-1 levels, which further enhances metabolic levels and stimulates lipolysis. Especially for parts such as the abdomen where fat is easy to accumulate and difficult to remove, the use of Tesamorelin is better.
In the Tesamorelin trial, after 3 to 12 months of treatment, the subjects' organ fat was reduced by 10 to 20 percent, and the average visceral fat was reduced by 18 percent.
Various experiments targeting Tesamorelin also showed that Tesamorelin treatment reduced fat mass while increasing lean muscle mass. Through changes in trunk muscles based on computed tomography (CT), it was found that compared with the placebo group, all trunk muscle groups of the subjects, Including rectus abdominis, anterolateral abdominis, psoas major and paravertebral muscles, total muscle density and area increased significantly.
Tesamorelin vs HGH
Tesamorelin acts on the front end of HGH, and although it also acts by stimulating the production and release of GH, it has two main advantages over the direct use of HGH.
One is that Tesamorelin is used in the process of reducing abdominal fat, which does not stimulate excessive GH secretion. So it does not bring the side effects of HGH excess.
Second, the direct use of HGH treatment can cause slight impairment of glucose metabolism in patients in a short period of time, while the use of Tesamorelin treatment can significantly reduce the amount of fat in obese individuals without affecting glucose metabolism.

Tesamorelin, a synthetic form of growth hormone-releasing hormone (GHRH), was approved by the FDA in 2010 for the treatment of HIV-related disorders of fat metabolism. Because it's approved for reducing belly fat in HIV patients, would we think it could be used for fat loss? And because it has the effect of GHRH, would we assume that it helps to raise GH and IGF-1 levels? So what are the facts, and why do Bodybuilders use Tesamorelin?
Tesamorelin and GHRH
Tesamorelin is derived from GHRH and is based on all 44 amino acid sequences of GHRH, with modifications added at the n-terminal. Tesamorelin is a modified GHRH. This modification increases its plasma stability and reduces renal clearance, making it more stable. It also increases its membrane permeability, making its effect more effective; It also lengthens its cycle half-life.
GHRH is a growth hormone-releasing hormone naturally produced by the human body that stimulates GH secretion by acting on GHRH receptors. GHRH is released as a pulse and stimulates GH pulse release. GH promotes liver secretion of IGF-1 and stimulates gluconeogenesis. GH is essential for maintaining muscle and bone mass and affects fat distribution in the body. Therefore, the effect of Tesamorelin on the human body is similar to that of GHRH, mainly through the action of GH and IGF-1.
Tesamorelin and fat loss
HIV patients after antiretroviral treatment, will affect the distribution of fat in the body, a large amount of fat is deposited in the abdomen, forming typical post-treatment symptoms.
Clinical trials have shown a 10-20% reduction in abdominal fat in patients after 3-12 months of treatment, and it is well tolerated with no side effects associated with GH excess.
Belly fat is often more difficult to get rid of than fat in other areas, and Tesamorelin helps to reduce belly fat in a targeted way.
Why do Bodybuilders use Tesamorelin?
Compared with the direct use of GH or IGF-1, the use of Tesamorelin acts on the front end of GH to stimulate the pulse release of GH, and does not produce the side effect of excess GH, which is relatively safer.