The main advantage of Sarms compared with AAS is that androgen side effects are less. PCT is required for every AAS cycle (except TRT). Does the sarms cycle need PCT?
It depends on the type of SARMs
A major problem that PCT addresses is the suppression of endogenous testosterone, so One criterion for determining whether a PCT is required for One sarms cycle is whether the sarms inhibit endogenous testosterone secretion.
Endogenous testosterone secretion is suppressed because the compounds used replace the role of testosterone in the body, fooling the body into thinking that sufficient levels of testosterone have been secreted, thereby reducing endogenous testosterone levels to maintain the total testosterone level in the body within the normal range. Therefore, whether an sarms needs PCT depends on whether it will replace the role of endogenous testosterone.
sarms are selective androgen receptor modulators, which act by binding with androgen receptors in skeletal muscle. Therefore, sarms will replace the role of endogenous testosterone (androgen), so that more self-secreted testosterone can be left, thus achieving the result of testosterone inhibition. Therefore, the sarms cycle requires PCT.
However, there is also a subset of receptor agonists, which are classified as sarms but do not actually work by binding to androgen receptors. mk677, for example, is a ghrelin receptor agonist and a growth hormone secretagogue that mimics the growth hormone (GH) stimulating effects of the endogenous hormone ghrelin. For example, GW501516 is a PPARδ receptor agonist that provides energy to the body by regulating lipid and protein metabolism, thereby greatly increasing endurance levels.
This type of sarms does not require PCT. Therefore, before using sarms, it is necessary to understand what kind of receptor modulator it belongs to in order to have the corresponding use.
Depending on the dose of SARMs used
When the sarms you use are true sarms (i.e., selective androgen receptor modulators), in principle, they inhibit endogenous testosterone secretion, so they need PCTS. But the advantage of sarms is that it is more secure. When you use it at low doses, it doesn't cause excessive side effects, including testosterone suppression. For example, lgd4033, studies have shown that when the daily dose is not more than 5mg, basically zero side effects, and the dose is 5-10mg, side effects are also very small. When the dose exceeds 10mg, the corresponding PCT should be selected according to the actual situation.
To sum up, do I need PCT after SARMs cycle? It depends on which sarm you're using, with what doses, and the cycle length, if there is any side effects.