Androgenic alopecia is a topic of increasing concern. Does the use of exogenous testosterone to boost overall testosterone levels cause androgenic alopecia hair loss?
I did a little poll on that question. Of the 351 male testosterone users, 43 experienced hair loss after using testosterone, and 351 reported no hair loss after using testosterone for more than a year, and some even had thicker hair after using extrinsic testosterone. The proportion of participants with and without hair loss is shown in the figure below.
Relationship between exogenous testosterone and hair loss
The reason why it is believed that exogenous testosterone causes hair loss is because the higher the level of testosterone, the more DHT will be converted, and thus the androgenetic alopecia. This is indeed the theoretical cause of baldness.
People who use exogenous testosterone instead of other steroids usually do so for the purpose of testosterone replacement therapy (TRT). Therefore, the dose of testosterone used is relatively low, about 200-300mg/wee, and the maximum will not exceed 500mg/week. This dose is used to make up for testosterone levels that decline with age or that are low due to hypogonadism. The purpose of using testosterone in these people is to raise the overall testosterone level to the normal level, or at the position of the normal testosterone level. If testosterone did not affect his hair when he was young and his testosterone level was the highest in his life, chances are that it will not affect his hair after increasing his testosterone level.
People with a family history of hair loss are more likely to lose hair. Therefore, if your hair is more sensitive to DHT, you belong to the population prone to hair loss. Before you use testosterone, your testosterone level may not be enough to convert enough DHT to cause hair loss, and when you use exogenous testosterone to convert more DHT, it may cause hair loss.
Why do I not lose hair after using exogenous testosterone?
First of all, genetics plays a big part, and if your genetics are good, you’ll always be able to keep your hair easily.
Estrogen levels have a lot to do with hair health. Elevated levels of testosterone, in turn, lead to elevated levels of estrogen. Proper estrogen contributes to the health of hair and makes hair grow better. But too much estrogen can cause more side effects in men. Testosterone users will use aromatase inhibitors (AI) to lower estrogen levels. If estrogen is reduced to too low a level, it can make hair quality worse and may lead to hair loss.
In addition, stress and emotional problems can also cause hair loss. After the male testosterone level increases, it will enhance self-confidence and improve physical health to a certain extent. Therefore, if you are not prone to hair loss, hair quality can be improved.
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Forums are full of people discussing the side effects of testosterone injections, why are so many people still using testosterone, and are they worth it?
Why do so many people discuss the side effects of testosterone injections on forums? This is because so many people are getting testosterone injections. Except for those who are well tolerated, have no side effects, or have all side effects resolved by the doctor, the base of people who come to the forum because the problem is not resolved is still that large. The fact that more and more people are talking about it indicates that the range of testosterone users is expanding.
We can see that in the process of using testosterone, many people talk about having to check their blood pressure regularly, quit smoking, control drinking, adhere to injections (may be lifelong injections, but also need to spend more money), and even need to take some additional drugs, such as liver protection, anti-estrogen and so on. That sounds like a complicated thing to do. Are the benefits of using testosterone worth all the things we do?
Except for the few who quit because of problems they couldn’t solve, most of them are sticking with it. So, the results are clear: worth it, especially for those with low testosterone levels.
When you are too tired to function every afternoon; When you want to participate in some outdoor activities, but are discouraged halfway up the mountain; When you lose muscle mass with age and your belly gets bigger… These little problems can knock your confidence and affect the quality of your life. However, problems such as fatigue, decreased self-confidence, decreased libido, muscle loss, and osteoporosis can all be solved by testosterone.
Will there are side effects of using testosterone?
Of course there will be. But every side effect has a solution, you just need to check regularly and follow your doctor’s advice.
Afraid of injections? Oral testosterone has even been developed to solve the injection problem. Worried about pain from intramuscular injections? Subcutaneous injections have also been found to be a good solution.
Long-term testosterone injections cost money? Compared to the libido, muscle mass, less effort, better fitness results, more extroversion, more confidence, more energy, spontaneous erections on demand, etc., increased testosterone levels are worth the cost (money). At the same time, isn’t making money for a better life?
Of course, before deciding to use testosterone, you should do a blood test, fully listen to the doctor’s advice, and do not start blindly, lest you will end more blindly.

For bodybuilders, we’ve talked a lot about how to boost your testosterone levels, such as exercising, Enclomiphene, or extrinsic testosterone. In talking about these topics, we are assuming that you are building muscle for the purpose of bodybuilder, today we are talking about normal conditions to increase testosterone levels.
Testosterone levels are important for bodybuilders, and equally important for every man. Testosterone makes men men. When we say someone has higher testosterone than others, it’s like saying they’re more masculine than others. How to increase testosterone levels is crucial for every man.
Maintain a healthy lifestyle
A healthy lifestyle helps boost testosterone levels. This includes eating a healthy diet, maintaining a balanced diet with protein and minerals and healthy fats, and eating less processed foods. In addition to eating a healthy diet, avoid smoking and excessive alcohol consumption, which would lower testosterone levels and also carry a number of health risks.
Maintain a healthy weight
Obese men have low testosterone levels that have been proven by studies, while overly thin men seem to have low testosterone levels. Therefore, maintaining a healthy weight will make you look like you have higher testosterone levels, which is actually the case. Regular exercise helps maintain healthy weight gain and increases testosterone levels. Getting enough sleep and managing your own stress can also help boost your testosterone levels and lead to a healthier body.
Avoid exposure to chemicals
With the development of agriculture and industry, the number of people with infertility and infertility is increasing, which is link to some chemicals present in pesticides and personal care products, which can interfere with hormone balance and affect male testosterone levels and fertility.
Consider natural supplements
Proper supplementation of vitamin D and zinc both help with testosterone production, but medical advice should be followed and may have the opposite effect if taken in excess.
Consider TRT
If your testosterone level is already very low and is beginning to affect your normal life, and natural ways have not been able to increase testosterone levels, you can consider TRT(testosterone replacement therapy).TRT is the use of external testosterone? <http://www.astersteroids.com/testosterone-base-injection-for-sell-muscle-building-dosage-cycle-and-half-life/>to replace the role of your own testosterone, so as to treat the problem of insufficient endogenous testosterone levels.

In the use of bodybuilding supplements, the most direct impact on the body is the inhibition of their own testosterone level, is there a growth of muscle mass without affecting their own testosterone levels of supplements?
AAS
AAS is an exogenous androgen. The use of exogenous androgen in the bodybuilding cycle will definitely affect the secretion of testosterone. During this process, the level of testosterone in the body may still in homeostasis, but this balance is not controll by HPTA(hypothalamic-pituitary-testicular axis), but the secretion of endogenous testosterone gradually decreases, and AAS supplements this part of testosterone and balances the levels of testosterone in the body at a higher level.
Sarms
SARMs are not androgens, and the use of sarms in the bodybuilding cycle theoretically does not affect endogenous testosterone levels. However, this is not the case. sarms work by binding to androgen receptors, and by taking up a portion of the androgen receptors, the body produces an extra portion of testosterone. The brain detects that there is more testosterone secreted and reduces testosterone production. Therefore, if you use sarms, you will still reduce some of your own testosterone levels.
How can I maintain a stable testosterone level while using AAS and sarms
Since both AAS and SARMS use reduce endogenous testosterone levels, is it possible to maintain normal testosterone levels in the process? It is possible to use these supplements to stack testosterone to replenish the testosterone that less produced. But in doing so, it still suppress the testosterone level.
So bodybuilders began experimenting with the use of gonadotropins in the cycle, which unblocks the inhibition of HPTA by high testosterone levels so that testosterone is release continuously . Enclomiphene is commonly to maintain the level of endogenous testosterone.
Are there supplements that don’t affect testosterone level at all?
In addition to natural additives and strengthening exercises, only a few that are classified as sarms are other receptor agonists (which do not act on androgen receptors) that do not affect testosterone levels. gw501516 <>, for example, helps build muscle by regulating metabolism to boost energy levels and endurance. However, these supplements are not as effective as sarms and AAS in building muscle.

For bodybuilders, a high or low level of testosterone is closely related to gaining and maintaining muscle mass and strength, and we generally think that the higher the level of testosterone, the easier it is to build muscle, so what is the maximum level of testosterone our body can effectively use?
Testosterone levels in relation to muscle mass and strength
The older you get, the more difficult it is to build muscle and maintain the muscle mass you’ve gained, mainly because testosterone levels in adult men decline with age. Similarly, men’s strength levels and bone health tend to decline as they age.
It is clear that low levels of testosterone are not conducive to building and maintaining muscle mass and strength, and are not conducive to the health of bones.
500mg/week testosterone dose could raise testosterone to what level?
Normal testosterone levels range from about 10-30 nmol/L, and under special circumstances, some people’s normal testosterone levels will exceed 30 nmol/L. So, with greater testosterone levels, can our bodies use them effectively?
The study showed that on day 14 after the first 500 mg (15.02±0.76 nmol/L) Test T, the participants’ testosterone levels increased by 360%, that is, about 54.07nmol/L (1557ng/dL), which is well above the maximum value of the testosterone range.
500mg/week is the dosage for novice bodybuiders and 1000mg/week for experienced bodybuilders. There is no experimental data on 1000mg/week doses, but if inject 1000mg of testosterone weekly, The maximum testosterone level in the blood is much higher than 1500ng/dL.
Is it necessary to use higher testosterone doses?
Bodybuilders use exogenous testosterone to build muscle by putting their bodies through tough workouts, they work very hard to make these testosterone would be use in building muscle mass and increase strength, Not to make yourself angry, aggressive, or more self-centered. However, they are still not immune to the side effects of high doses of testosterone, so the corresponding side effects need to be addressed in cycle and PCT.
So, if you do not have a reasonable plan, blindly increase their serum testosterone levels, perhaps the final result will not be as you want.

Testosterone is the basis of all anabolic steroids. When bodybuilders start the steroids cycle, testosterone is usually the first thing they consider, which can help build muscle quickly and reduce fat, improving boybuilders' exercise ability. When bodyuilders use testosterone to build muslce, what are the other effects? Let's take a look at what testosterone users have to say.
Relieve social anxiety and increase self-confidence
“My anxiety has reduced a ton in social situations. I’m able to relax and completely unaware of how people perceive me anymore. My partner was like...when did you turn into such a chill cool guy?”
“Same here I went from extremely mentally unstable and even suicidal to MUCH happier, more confident, higher energy within just a couple months.”
Hair loss may occur, but body hair may increase
“I thought ‘I’m hairy as is. It can’t get much worse’. It got worse.”
“I had to trim my thigh hair with clippers.”
Hot flash
“Menopause lol. Hot flashes aren’t fun but it’s temporary”
“My endocrinologist told me this was a symptom actually haha, but it isn’t permanent. She told me that it usually comes back when you go off of Testosterone though. ”
Increase libido
“Libido, went from getting off 1-2 times a week to 1-2 times a day.”
Muffled voice
“With the singing, it took me 6-7 months to really start singing again because my voice was changing too rapidly to sing without sounding horrible. As it’s settled I’ve found I don’t have the same tone and stuff as I did before, but almost like a completely new voice. Just give it some more time.”
Sweat easily
“No more hot showers, less resistance to hot weather and sweating all over my body when i’m exerting myself was a surprise to me.”
Muscles get stiff if you don't exercise
“It will make you bulk up muscles even if you don’t work out, but you need to stretch like you are going to exercise every day otherwise you can get stiff and uncomfortable.”
“Stretching is super important. I had been wondering for a while why I was always so stiff and then I read a post here about someone experiencing stiffness on Testosterone, it all made sense.”
Increased appetite
“You will want to eat the entire house lol.”
“The fridge tempts me in ways I never experienced before. And I have no idea whether to listen to the urge to eat everything or resist it.”
Knowing the possible effects of testosterone in advance can help you prepare for entering the cycle in advance, and don't panic if you encounter these conditions in the cycle, many symptoms will ease over time, if a certain symptom has affected your daily life, please seek medical help in time.

When bodybuilders try a new supplement, they are usually told to start with the lowest dose to test the body's tolerance and reduce side effects. We usually use Peptides follows this principle: start with a low dose and gradually increase to the target dose. Testosterone is the foundation of all AAS and is the first choice for boosting your body's testosterone levels. Use testosterone to build muscle, should i start with a low dose?
What's the dose of testosterone?
Studies have shown that 100-125mg of testosterone per week can increase testosterone levels to baseline levels: 500-600ng/dL, and 300-600mg of testosterone per week can increase testosterone levels in users to 1300-2300ng/dL. Testosterone levels in normal adult males range from 300 to 1000ng/dL.
From these data, we can see that if the user has low levels and wants to raise their testosterone level to the baseline level to get rid of the effects of low testosterone levels, 100-125mg per week is the lowest dose level. If the user wants to use testosterone for muscle building purposes, 300-600mg per week is the lowest testosterone dose.
Different individuals have different adaptive dosages, and bodybuilders use testosterone to build muscle, usually starting at 500mg per week and ranging from 500 to 700mg per week.
Should I start with a low dose?
Before using a new supplement, it is often preferred to start with a low dose to test the body's tolerance and reduce the body's response to the drug. Does this type of drug use apply to testosterone?
When a person with normal testosterone levels comes to build muscle using testosterone, in addition to androgen side effects, the first consideration is testosterone suppression. How does testosterone inhibition happen? As long as there is exogenous testosterone into the body, the natural testosterone production will be less, and a steady stream of exogenous testosterone into the body, the body's natural testosterone production will be less, and a little less. Testosterone suppression can occur even when small doses of exogenous testosterone are used. However, if the testosterone dose is too small, it will not produce a good muscle building effect.
For muscle building, a superphysiological dose of testosterone is required, so if the exogenous testosterone level is too low, you can't raise your own testosterone level to the superphysiological level, there is not much effect on muscle building. Therefore, most of the time, the testosterone dose for building muscle starts at 500mg, and too low a dose may not achieve the desired effect. Of course, it cannot be ruled out that some individuals are sensitive to testosterone, and the use of 500mg will bring serious side effects, in which case the dose needs to be reduced.

If we don't know exactly what testosterone does, we can easily name a few. If you ask how testosterone works, most people probably don't know. Today, we will take a brief look at it.
What's the use of that, you might say? Who knows, maybe one day you'll need it, maybe someone just needs the knowledge.
The action of testosterone is through a combination of many different pathways, at the cellular and organ level, the action of testosterone does not depend on genomic mechanisms, most of the action is through the binding of hormone receptors. Bound androgen receptors act as transcriptional regulatory elements by binding to specific DNA response elements in target gene promoters, causing activation or inhibition of transcription and subsequent protein synthesis.
Effects on muscle mass and strength
The effects of testosterone on muscle mass and strength occur primarily through binding to androgen receptors. The degree to which it works is positively correlated with the dose used, and if the dose used is too low, it may not have any effect.
A study giving testosterone enanthate 200mg every 2 weeks found that an increase in mass was observed after 12 weeks, with the greatest effect achieved after 6-12 months. This is a very small dose at which improvements in muscle mass and strength are observed.
Effect on bone mineral density
The effect of testosterone on bone mineral density is mediated by estrogen, which acts on testosterone derivatives produced after the interaction of testosterone with aromatase.
In the study, testosterone continued to improve lumbar bone mineral density from 6 months to 36 months.
Effect on lipids
Testosterone plays an important role in obesity, glucose homeostasis and lipid metabolism. It promotes myogenic differentiation of mesenchymal pluripotent cells through androgen receptor-mediated pathway and inhibits their differentiation into fat. After using testosterone, fat mass will decrease and lean body mass will increase. There is no significant change in total weight at the beginning, and in general, total mass begins to increase after 3 months.
Testosterone induces changes in lipid metabolism and changes in insulin signaling after the receptors in the muscles as well as an increase in insulin sensitivity, resulting in a decrease in total cholesterol levels and triglyceride levels.
Testosterone treatment also has a variety of effects such as lowering blood pressure, promoting cardiovascular health, reducing inflammation, and promoting sexual desire, affecting many parts of the body as well as physical and mental health.

Since its discovery and in-depth study by biologists, testosterone has provided many new directions for human health and disease treatment. When testosterone is used for medical purposes, it usually comes in the form of exogenous testosterone, which is used to supplement or replace the body's naturally produced testosterone and has an irreplaceable role. There are various forms of medical testosterone available, and This blog will begin with a few forms when using testosterone for medical purposes.
Take orally
Oral testosterone is easy to use, but it is metabolized by the liver and has low bioavailability, so oral testosterone is not widely used. The orally available testosterone is testosterone undecanoate (TU). The alkylation of testosterone on C17α produces testosterone derivatives with the ability to bypass first-pass metabolism, but with certain hepatotoxicity, such as methyltestosterone
Injection
Intramuscular injections are the most common form of testosterone use. Common ones are to test cypionate and test enanthate, which allow for the slow release of testosterone into the bloodstream, providing stable testosterone levels for 1-4 weeks.
Topical gels and creams
These include 1% and 2% testosterone gels applied daily to the skin and absorbed through the bloodstream. The testosterone levels they provide are fluctuating, but they are more convenient to use and provide a convenient option for testosterone supplementation.
Testosterone patch
These drug patches are placed on the skin and deliver a certain amount of testosterone into the bloodstream. They are usually attached to the arms or upper body and sustainably release testosterone. Change every 24-72 hours depending on the specific patch.
Testosterone pellets
During minor surgery, subcutaneous pellets are surgically implanted. This small pill slowly releases testosterone over a period of 3-6 months, providing long-lasting effects. It was the first effective formulation developed in the 1940s.
Testosterone in the oral system
Oral dosing was originally approved by the FDA in 2003. This use delivers testosterone directly to the systemic circulation and bypasses the liver, avoiding first-pass metabolism and improving bioavailability.
This involves placing a testosterone tablet between the cheek and gums and slowly releasing testosterone into the body. It needs to be changed twice a day.
Low testosterone levels are associated with a shorter life span and an increased risk of many diseases, as well as sexual dysfunction, muscle and bone degradation, out-of-shape shape, metabolic disorders, and decreased immunity, endangering physical and mental health. Fortunately, with the development of science and technology, and the in-depth study of testosterone and its derivatives, the phenomenon of low testosterone can be well s...

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Testosterone is a naturally occurring male sex hormone in the human body. It is produced mainly in the testicles of men and in small amounts in the ovaries and adrenal glands of women. Testosterone is a steroid compound with a typical sterane core structure consisting of three carbon five-membered rings and one carbon four-membered ring. It has the formula C19H28O2 and belongs to the androstane family, specifically the 17-β-hydroxy-androstane-3-1 family.
The main chemical characteristics of testosterone
1. Two hydroxyl groups in the C-19 position. Through these two hydroxyl groups, testosterone can bind to testosterone receptors and exert biological activity.
2. A hydroxyl group at the C-17 position. By migrating the hydroxyl group, the effect of estrogen is generated.
3. Seven carbon-carbon double bonds. These carbon-carbon double bonds give the molecule a planar structure that facilitates binding to testosterone receptors.
The structure of testosterone determines its biological function
1. After binding to testosterone receptors, it activates related signal transduction pathways, promotes muscle protein synthesis, increases muscle size and strength, helps maintain bone density and prevent osteoporosis. At the same time, it regulates secondary sexual characteristics, such as stimulating sperm production, affecting sexual desire and sexual function.
2. The hydroxyl group of C-17 is easily reduced to a keto group, producing dihydrotestosterone (DHT), which has a higher affinity and can more effectively promote the development of secondary sexual characteristics and maintain sexual function.
3. Testosterone can be converted into estrogen through the displacement reaction and the removal of hydroxyl groups, which has the role of regulating secondary sex characteristics and promoting bone health.
4. Testosterone has a typical sterol structure, which is conducive to its passage through biofilms. And can bind SHBG and other binding proteins, convenient transport in the blood, play a role in various parts of the body.
5. Variations in the structure of testosterone can produce different derivatives or analogues with different biological effects and pharmacokinetic properties, playing a huge medical role.
In summary, the chemical structure of testosterone determines its multiple biological effects. From the chemical structure, we can know what role it may have. Through the study of its chemical structure, biologists can find and synthesize a variety of testosterone derivatives, which play different roles in different fields and provide new treatments for health and disease.