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How to solve the problem that semaglutide weight loss does not work after the plateau?
Weight-loss drugs have a plateau, after which further weight loss is slowed or stopped. What should I do when semaglutide weight loss plateau appears ?
Semaglutide plateau
Semaglutide weight loss As with other weight loss methods, the body will eventually stabilize at an appropriate weight, which may or may not be the user’s goal weight. If you want to continue to lose weight after reaching the weight loss plateau of the drug, or to avoid weight regain, you need to take the drug for life.
Semaglutide is an FDA-approved weight loss drug. It mimics a naturally occurring hormone that provides the brain with a sense of fullness, slows digestion, and allows food already consumed to leave the body more slowly, successfully helping many obese people lose significant amounts of weight. However, after the weight reaches a certain point, the rate of weight loss slows down until it stops.
Semaglutide plateaus after about 60 weeks of continuous use. At this point, the user has usually lost a significant amount of weight and is gradually approaching a healthy weight, and the body is more inclined to retain calories to protect itself.
At the beginning of weight loss, when you reduce your energy intake, your body will meet its energy needs from other sources such as glycogen (including breaking down fat), which will lead to weight loss. Over time, as the weight lost gradually increases, the body compensates by slowing down the metabolism. When your metabolism is equal to the amount of energy you take in from food, you’ve hit a plateau. This is the genetic protection of the body, which also leads to the cessation of weight loss.
How to solve the semaglutide plateau
If you need to cross the plateau and start losing weight again, you need to change the body’s energy balance again. This can be done by changing your diet or increasing physical activity.
Another way to change the plateau is to increase the dose of the drug. The dose of Semaglutide is 1mg to 2.4mg per week, with gradual increases from the lowest dose to the highest dose. However, after reach the maximum dose, we can’t increase the dose, otherwise it will bring more side effects. So increasing the dose of the drug is limite.
The slimming peptide Tirzpatide <https://www.astersteroid.com/tirzepatide-a-new-dual-action-type-ii-diabetes-drug-showed-better-weight-loss-results-than-semaglultide/> and Retatrutide <https://www.astersteroids.com/triple-receptor-agonist-peptides-retatrutide-ly-3437943-benefits-in-weight-loss/> developed successively also indirectly solved the problem of plateau of Semaglutide <https://www.astersteroids.com/type-2-diabetes-treatment-semaglutide-wegovy-fda-approved-for-healthy-weight-loss/>. Semaglutide is a single receptor agonist of GLP-1, Tirzepatide is a double receptor agonist of GIP and GLP-1. Retatrutide is a triple receptor agonist for GIP, GLP-1 and GCG. Thus, there is equivalent to a progressive relationship between the three drugs, and... -
What is the maximum testosterone level that the body can use effectively?
For bodybuilders, a high or low level of testosterone is closely related to gaining and maintaining muscle mass and strength, and we generally think that the higher the level of testosterone, the easier it is to build muscle, so what is the maximum level of testosterone our body can effectively use?
Testosterone levels in relation to muscle mass and strength
The older you get, the more difficult it is to build muscle and maintain the muscle mass you’ve gained, mainly because testosterone levels in adult men decline with age. Similarly, men’s strength levels and bone health tend to decline as they age.
It is clear that low levels of testosterone are not conducive to building and maintaining muscle mass and strength, and are not conducive to the health of bones.
500mg/week testosterone dose could raise testosterone to what level?
Normal testosterone levels range from about 10-30 nmol/L, and under special circumstances, some people’s normal testosterone levels will exceed 30 nmol/L. So, with greater testosterone levels, can our bodies use them effectively?
The study showed that on day 14 after the first 500 mg (15.02±0.76 nmol/L) Test T, the participants’ testosterone levels increased by 360%, that is, about 54.07nmol/L (1557ng/dL), which is well above the maximum value of the testosterone range.
500mg/week is the dosage for novice bodybuiders and 1000mg/week for experienced bodybuilders. There is no experimental data on 1000mg/week doses, but if inject 1000mg of testosterone weekly, The maximum testosterone level in the blood is much higher than 1500ng/dL.
Is it necessary to use higher testosterone doses?
Bodybuilders use exogenous testosterone to build muscle by putting their bodies through tough workouts, they work very hard to make these testosterone would be use in building muscle mass and increase strength, Not to make yourself angry, aggressive, or more self-centered. However, they are still not immune to the side effects of high doses of testosterone, so the corresponding side effects need to be addressed in cycle and PCT.
So, if you do not have a reasonable plan, blindly increase their serum testosterone levels, perhaps the final result will not be as you want. -
Will testosterone level rise naturally without the use of exogenous testosterone?
For many people, 300ng/dL is a very low testosterone level. If the testosterone level is this value, there may be certain symptoms of low testosterone. However, normal testosterone levels range from 264 to 916ng/dL, indicating that 300ng/dL is a normal value. Why is there such a wide range of testosterone levels?
This is because men’s testosterone <> levels are constantly changing throughout their lives, and this change generally follows the same rule, that is, “with the growth of age, and year by year.” The age of 20 is about the highest level of testosterone in a man’s life, and after that, testosterone levels will decline every year.
Does anyone’s testosterone level rise from year to year?
It is true that there are people whose testosterone level rise with age without the use of exogenous testosterone and other drugs that promote testosterone production. Here is a case study of a 40-year-old man with a blood test result of total T=1082 and Free T=10. According to him, he did not use exogenous testosterone, nor did he use other drugs that would promote testosterone production.
The hypothalamic-pituitary-testicular axis (HPTA) controls the secretion of testosterone. When the body’s testosterone levels are low, HPTA activates positive feedback to start promoting testosterone secretion. When the body’s testosterone level reaches the maximum threshold, HPTA initiates a negative feedback that begins to inhibit the secretion of testosterone, so that the testosterone level is in dynamic equilibrium.
The normal testosterone level is between 264 and 916ng/dL, the maximum 916 is about the testosterone level of a man when he is 20 years old, and the minimum 264 is the testosterone level of an elderly man. What happens if a man reaches the age of 40 and finds that his testosterone level exceeds 1,000 ng/dL? Of course, at first you might be happy, like you’re 20 again. Then, you might worry, is there something wrong?
What’s the problem?
When the testosterone level exceeds the maximum of this age, the first thing to consider is whether there is a problem with HPTA, at this time, the pituitary gland is usually checked, whether the pituitary tumor affects the function of HPTA.
If the test is completed and no physical problems are found, it is also possible to have a testosterone level of 1000ng/dL at the age of 40, and it is said that some young men in the Colombian army test for testosterone levels as high as 1500 ng/dL, which may be related to genetics.
Are there other factors that cause testosterone levels to rise? It is said that this man measured his testosterone level above 1000 after he lost weight. Do you know how much weight he lost? Two hundred pounds. And he’s still on a diet.
Some experiments have shown that fasting increases testosterone levels. At the same time, he has lost a ... -
Why do man with high testosterone level would have low testosterone symptoms
Normal testosterone levels are between 264 and 916ng/dL, while some men with high testosterone level around 1000ng/dL still have low testosterone symptoms, including severe fatigue, slow recovery from exercise, libido problems, mild ED, depression, anxiety, and even reduced erections in the morning. Today we talk about possible causes.
Production and form of testosterone
The hypothalamic-pituitary-testicular axis (HPTA) controls the release of testosterone. After testis release the testosterone , this part of testosterone does not enter the blood circulation directly, but part of it bind to SHBG (sex hormone binding globulin), part of it bind to albumin, and only a small part (about 2%) unbind and can bind freely to androgen receptors. To make a difference. Therefore, this part of the unbound state of testosterone is Free T. The higher the level of Free T, the more benefits of high testosterone levels.
In addition to Free T, a portion of testosterone binds to albumin. Albumin is a carrier protein that has a low binding force with testosterone and can easily separate from the bind testosterone. This testosterone, which binds to albumin, arrive various parts of the body in the blood circulation. And then when testosterone separate from albumin, it also acts as testosterone.
The part of testosterone that binds to SHBG is difficult to separate from SHBG because it has a high affinity with SHBG. Therefore, this part of testosterone is equivalent to being wasted, unable to produce corresponding effects.
Conclusion
So, Free T is the most potent testosterone, followed by albumin bound testosterone, and finally SHBG bound testosterone. When we take a blood test, the total testosterone measured includes the part of the testosterone that is bound to SHBG, so when the total testosterone level is high, it does not mean that the body has a high level of available testosterone.
When you have a high testosterone level and, at the same time, a high SHBG level, then you are still likely to have low testosterone symptoms.
Boron helps reduce SHBG levels. There is also Proviron , a weak anabolic steroid that preferentially binds to SHBG, increasing the level of free testosterone and improving the utilization of testosterone and other AAS. -
Compare Hexarelin Acetate and Ghrelin: Unlocking the secret of stimulating growth hormone secretion
GHRH (growth hormone releasing hormone) based on the development of growth hormone secretadotropin, because it is a synthetic form of GHRH or a cut from the amino acid sequence of GHRH, and has a similar role to GHRH in promoting HGH secretion. Hexarelin Acetate , on the other hand, has a different structure than GHRH, but is rather similar to GHRP-6, mimicking the effects of Ghrelin by acting as a Ghrelin receptor agonist. So, what is the relationship between Hexarelin Acetate and Ghrelin, and how do they increase HGH levels?
Hexarelin Acetate: a synthetic peptide
Hexarelin Acetate is a synthetic peptide derived from the growth hormone releasing peptide (GHRP) family. It was originally developed to stimulate the release of growth hormone and promote growth in laboratory animals. The main mechanism of action of Hexarelin involves binding to the auxin receptor, the growth hormone secretagotor (GHS-R1a). By activating this receptor, Hexarelin effectively stimulates the pituitary gland to release more growth hormone into the blood.
Ghrelin: The natural hunger hormone
Ghrelin is a natural peptide hormone that plays an important role in regulating hunger and appetite. It is produced mainly in the stomach and is released when the stomach is empty, signaling the brain to eat. Ghrelin also binds to the GHS-R1a receptor, much like Hexarelin, but its main function is to stimulate the release of growth hormone during fasting or calorie restriction.
Hexarelin Acetate and Ghrelin: growth hormone stimulation
Both Hexarelin Acetate and ghrelin have the unique ability to stimulate the release of growth hormone in the body. This common mechanism of action makes them valuable tools in the fields of research, medicine and exercise science. Increased levels of growth hormone can have a range of benefits, including promoting muscle growth, reducing fat, improving energy, and potentially anti-aging effects.
Key differences between Hexarelin Acetate and Ghrelin: natural and synthetic
The most significant difference between Hexarelin and Ghrelin is their origin. Ghrelin is a naturally occurring hormone, while Hexarelin is a peptide synthesized in the lab. The main role of Ghrelin is to regulate hunger and appetite, while Hexarelin is specifically designed to stimulate GH release. Although the two compounds activate the same GHS-R1a receptor, their effects differ due to the synthetic nature of Hexarelin. -
Do I need PCT after a sarms cycle?
The main advantage of Sarms compared with AAS is that androgen side effects are less. PCT is required for every AAS cycle (except TRT). Does the sarms cycle need PCT?
It depends on the type of SARMs
A major problem that PCT addresses is the suppression of endogenous testosterone, so One criterion for determining whether a PCT is required for One sarms cycle is whether the sarms inhibit endogenous testosterone secretion.
Endogenous testosterone secretion is suppressed because the compounds used replace the role of testosterone in the body, fooling the body into thinking that sufficient levels of testosterone have been secreted, thereby reducing endogenous testosterone levels to maintain the total testosterone level in the body within the normal range. Therefore, whether an sarms needs PCT depends on whether it will replace the role of endogenous testosterone.
sarms are selective androgen receptor modulators, which act by binding with androgen receptors in skeletal muscle. Therefore, sarms will replace the role of endogenous testosterone (androgen), so that more self-secreted testosterone can be left, thus achieving the result of testosterone inhibition. Therefore, the sarms cycle requires PCT.
However, there is also a subset of receptor agonists, which are classified as sarms but do not actually work by binding to androgen receptors. mk677, for example, is a ghrelin receptor agonist and a growth hormone secretagogue that mimics the growth hormone (GH) stimulating effects of the endogenous hormone ghrelin. For example, GW501516 is a PPARδ receptor agonist that provides energy to the body by regulating lipid and protein metabolism, thereby greatly increasing endurance levels.
This type of sarms does not require PCT. Therefore, before using sarms, it is necessary to understand what kind of receptor modulator it belongs to in order to have the corresponding use.
Depending on the dose of SARMs used
When the sarms you use are true sarms (i.e., selective androgen receptor modulators), in principle, they inhibit endogenous testosterone secretion, so they need PCTS. But the advantage of sarms is that it is more secure. When you use it at low doses, it doesn't cause excessive side effects, including testosterone suppression. For example, lgd4033, studies have shown that when the daily dose is not more than 5mg, basically zero side effects, and the dose is 5-10mg, side effects are also very small. When the dose exceeds 10mg, the corresponding PCT should be selected according to the actual situation.
To sum up, do I need PCT after SARMs cycle? It depends on which sarm you're using, with what doses, and the cycle length, if there is any side effects. -
If I only run one cycle, is it still dangerous?
If we do have a certain disease, and the doctor prescribes the corresponding drug and tells us that this drug will have multiple side effects such as this and that, we will still take that drug. And when there is a healthy person, going to try a drug, we’re going to pay more attention to the side effects of the drug, and in the meantime, we’re going to think over and over again, do I want to use it?
People had the same idea before they tried steroids or sarms, not sure if they were going to start using them. At this point, many people will tentatively think, I try to do one cycle, and then stop. I will do the PCT correctly, get the body indicators back to normal, and then the muscle mass retained during this cycle (maybe 10 pounds, more or less) will be enough to achieve my goal.
Is this feasible? Of course you can. The use of steroids or sarms is a bodybuilding cycle, then follow by a PCT, and we can start the second cycle after the body indicators return to normal. If you finish the first cycle, it’s perfectly possible to stop and not go to the next cycle.
However, can you really stop after one steroids /sarms cycle?
Unless your experience in the first cycle is so bad that you jump out of the cycle without lasting even one cycle, you won’t hesitate to stop.
Suppose you get 10 pounds of muscle mass after the first steroids cycle, and you feel a lot of energy, a lot of power gains, a lot of confidence in the cycle, or you get the best performance ever on sports. After the cycle, you run the PCT cycle correctly, and all the side effects are eliminated and your testosterone <https://www.astersteroids.com/steroids-powder/testosterone-powder/> levels are restored.
Then, you stop and don’t do the next cycle. It’s doable. You may be able to hold yourself together for a few months during this period and not start a second cycle. But when everything settles down, you’ll be in the same state as you were before you started the first cycle. You can’t help but think, if you don’t use steroids, you’re not going to be able to get any further than you are now, and what’s more interesting to you is that the last cycle was so good, you want to run another cycle.
Whether it’s improving your appearance or increasing your confidence, it makes you a better version of yourself. This kind of improvement is addictive, and it’s hard to suppress your thoughts. A lot of people with a trial mindset will go through one cycle and then go through the second cycle and then the third cycle, and that’s probably why steroids are so widely used.
So, it’s possible to just run one steroids/sarms cycle. The premise is that you need to find the right supplements for your use, develop the right cycle, deal with possible side effects, and have a correct pct. Otherwise, you may not last a cycle. -
Clomiphene vs Enclomiphene Ocular sides and causes
In the process of using AAS or sarms, you can choose to use different AAS or choose one from a number of sarms, but you can hardly avoid SERM clomiphene or enclomiphene. men with low testosterone levels also use Clomid or enclo to boost their testosterone levels. In the course of the use of various drugs, there may be some side effects, but most of the side effects are reversible. Because clomiphene has a possible (rare) irreversible ocular side effect, those who know it will choose it carefully. If you were told that enclomiphene has the same benefits as clomiphene, but without the ocular side effects, would you choose enclomiphen over Clomiphene ? So when it comes to the ocular sides, what does clomiphene vs enclomiphene actually look like?
Clomiphene Ocular sides
Studies have shown that it is possible to have ocular sides when use clomid, such as blurry vision. Although this side effect is very rare, once it develops it is permanent.
Enclomiphene Ocular sides
A large proportion of the population claims that enclo has no ocular sides. If you still have ocular sides after using an enclo, you’re not getting enclo, you’re getting clomid. It is possible that someone might sell clomid as enclo. But the assumption is that enclomiphene does not introduce ocular sides, otherwise, whether you use clomid or enclo, ocular sides are likely to appear.
There’s not a lot of data on Enclo, and there’s no evidence that it causes eye problems. However, users reported that they had eye problems when using clomiphene, and enclomiphene continued to have eye problems after they changed to Enclomiphene following the advice. If it uses real enclomiphene, enclomiphene will also cause ocular sides.
Why Clomiphene vs Enclomiphene cause Ocular sides
There are many theories as to why clomiphene and Enclomidphene may cause eye problems, and since there is no official explanation, here is only an explanation.
Some explain this phenomenon from the way clomid and enclo function. They inhibit the negative feedback of HPTA by blocking the action of estrogen in the brain, thereby maintaining the release of testosterone. So they also blocks estrogen receptors in the eye, causing ocular sides.
Some explain this phenomenon in terms of the biological characteristics of clomid and enclo. Most SERMs, including clomid and enclo, are inhibitors of the enzyme DCHR24, whose role is to convert desmosterol into cholesterol. The first drug used to lower cholesterol was Triparanol, which worked by inhibiting DCHR24, but with serious adverse effects, including irreversible vision loss. Similarly, clomid/enclo inhibits the action of the DCHR24 enzyme, preventing desmosterol convert into cholesterol, which accumulates in the eye and causes ocular sides.
Clomiphene vs Enclomiphene. clomid is composed of enclomiphene and Zuclomiphene. As an inhibitor of DCHR2... -
When should I use SERM enclomiphene/clomiphene in the sarms cycle?
Some sarms, such as gw501516 and sr9009, we believe do not inhibit endogenous testosterone secretion and therefore do not need to use SERM clomiphene or enclomiphene. Other sarms, such as mk2866 and rad 140, mimic the mode of action of testosterone and inhibit endogenous testosterone production, requiring the use of SERM. Regarding when to use SERM, is it at the beginning of the cycle, in the middle of the cycle, near the end of the cycle junction, or after the cycle (PCT)? Different people have different opinions, and we have summarized these opinions.
We have talked a lot about the use of SERM after cycle (PCT), and if SERM is used during the period, sarms users prefer to use enclomiphene rather than clomiphene. In fact, in pct, they also use enclo. Today, we will not talk about the difference between enclo and clomid, but about which phase in the cycle they use serm.
Use SERM enclomiphene on the first day
A large percentage of bodybuilders prefer to use a SERM enclo on the first day of the cycle. They believe that sarms (mentioned here are inhibitory Sarms such as rad140, not non-inhibitory Sarms such as gw501516) mimic the action of testosterone, and it will start to exert inhibitory effects from the moment it enters the body, so you need to use serm enclo to maintain your endogenous testosterone secretion levels.
In terms of inhibition, the idea is correct. Doing so keeps endogenous testosterone levels uninhibited and at normal levels.
Start using serm enclomiphene in the second week of the cycle
Bodybuilders, who hold this view, believe that with stronger sarms like RAD140, which have a very high inhibitory effect, there is a possibility of more severe testosterone inhibition or shutdown in the fourth week of the cycle, so it is necessary to start enclo earlier, preferably no later than the second week of the cycle.
Many people agree with this view, because for safety reasons, no one wants to have their testosterone levels severely suppressed or shut down. There is a dosing issue involved, rad140 is given in doses of 10-30mg ED. Low doses of rad140 can be effective, and rad140 is used at low doses without severe testosterone suppression.
The serm enclo starts on the fourth week of the cycle
Some sarms start in the fourth week, with noticeable changes in muscle mass to strength levels, which is when hormone levels in the body are thought to be highest, after which total testosterone levels begin to decline (inhibition begins to show). At this time, SERM enclo is used to block the negative feedback effect of estrogen on HPTA, ensure the continuous release of testosterone, maintain testicular function, and maintain the testosterone level after the cycle.
Use a SERM enclo after the end of the cycle (PCT)
Post-cycle therapy (PCT) is the official procedure for the sarms or AAS cycle. Compa... -
How to solve the high estrogen levels problems caused by AAS use
Estrogen in men is produced by the action of aromatase on testosterone, and this part of estrogen plays a key role in male health. When male bodybuilders take AAS, testosterone levels rise rapidly in the body, and estrogen levels rise accordingly. High estrogen levels can have a range of effects on male bodybuilders, including bone health, moodiness, gyno, and more. How to solve the problems caused by high estrogen levels that may occur during AAS use?
Use AI(Aromatase inhibitors)
Where does estrogen come from in men? Because aromatase converts testosterone into estrogen. We couldn't try to lower testosterone levels, so we targeted aromatase. Both AI letrozol and arimidex bind to estrogens converted by aromatase, so that this part of the estrogen cannot bind to the corresponding estrogen receptors, thus reducing the effect of estrogen. The effect of AI ememestan/Aromasin is more direct, it directly kills aromatase, so that testosterone can not be converted into estrogen.
How these three AI are selected is related to the estrogen levels of the bodybuilders, but also to the corresponding estrogen symptoms. Used only to prevent high estrogen levels or early estrogen symptoms, Arimidex is usually used at 0.5mg per week or every 3.5 days. aromasin needs attention because it kills aromatase, the body needs time to produce new aromatase, in the process, there may be low estrogen symptoms. Letrozole reduces estrogen levels by 98%, so it is not often used in the AAS cycle, but in PCT or for the treatment of gyno.
Use AAS that do not convert to estrogen
AAS can be divided into two main categories, testosterone and DHT. Testosterone is converted to estrogen, whereas DHT is not. So using DHT-type AAS can avoid the side effects of estrogen. Testosterone AAS include testosterone, trenbolone, nandrolone, boldenone, dianabol. DHT AAS include Masteron, primobolan, anavar, winstrol, anadrol, proviron, superdrol. Some bodybuilders are better tolerant to estrogen, and some bodybuilders are more sensitive to estrogen and are prone to high estrogen symptoms. Therefore, it is possible to choose whether to use testosterone aas or DHT AAS based on this category. This is not to say that DHT-like AAS are better, DHT does not have estrogenic side effects, but there are androgenic side effects that belong to it.
Within these AAS, there are also special presence that give bodybuilders more options. Testosterone use aromatizes the production of estrogen, so estrogen side effects need to be dealt with. However, if masteron is combined with testosterone, there is no need to worry about estrogen side effects. Because masteron itself does not aromatize into estrogen, it also has anti-estrogen effects, and when it is used with testosterone, it enhances the effects of testosterone and avoids high estrogen side effects.
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