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Side effects review when use Triiodothyronine T3 for bodybuilding
Triiodothyronine T3 is not an anabolic steroid, but it plays a similar role to anabolic steroids to some extent.Triiodothyronine T3 is not an anabolic steroid, but it plays a similar role to anabolic steroids to some extent. Although it is a drug used to treat hypothyroidism, but as a hormone (thyroid hormone), bodybuilders use it in the process, there will be corresponding side effects.
Thyroid axis inhibition
The first is the inhibition similar to that of anabolic steroids. Exogenous T3 inhibits pituitary secretion of thyrotropin hormone (TSH) and thyroid secretion of thyroid hormone through negative feedback mechanism, and long-term inhibition of thyroid axis may lead to thyroid dysfunction. Heavy use of exogenous T3 may lead to hyperthyroidism, especially an overactive thyroid with symptoms such as rapid heartbeat, anxiety, sweating, weight loss, and fatigue.
Bone loss
Triiodothyronine T3 promotes skeletal muscle use of minerals such as calcium and phosphorus, which helps bone growth and development. Long-term use of it may lead to decreased bone density and an increased risk of osteoporosis and fractures.
Metabolic disorder
T3 causes the metabolism to accelerate, resulting in rapid weight loss, increased heat production, and excessive sweating. If you do not exercise, the breakdown of muscle proteins will occur, resulting in muscle loss.
Heart problem
T3 also has an impact on the cardiovascular system, leading to increased heart rate, palpitations, high blood pressure and an increased risk of arrhythmia. These effects can be especially dangerous for people who already have heart disease.
Sleep problem
T3 increases the basal metabolism, which can cause problems with excitement, insomnia, light sleep and more.
Psychological influence
T3 use can also affect mental health. Some people may feel anxious, irritable, mood swings, etc. These psychological side effects may sometimes affect normal work and life.
The thyroid hormone T3 is a powerful hormone that plays an important role throughout the body, and care should be taken to test the level of thyroid hormone in the body at any time during the use of T3. At the same time, do not overuse it for a long time to avoid serious side effects. -
Under what circumstances I can not get prescription testosterone?
With the increase of age, natural testosterone levels will gradually decline, and will have a certain impact on the body,With the increase of age, natural testosterone levels will gradually decline, and will have a certain impact on the body, supplementing exogenous testosterone will promote the health of the body. However, testosterone is available by prescription. Can I get a prescription for testosterone?
Whether you can get a testosterone prescription, you first need to measure whether your testosterone level is lower than normal. If the test results show that your testosterone levels are in the normal range, a healthcare professional will generally not prescribe testosterone or AAS. Only patients who have been clinically diagnosed with lower than normal testosterone levels, or who have been diagnosed with hypogonadism, may receive external testosterone.
However, a diagnosis of a lower than normal level of testosterone does not necessarily require a prescription of testosterone. If you test for low testosterone but do not show symptoms associated with low testosterone, a healthcare professional may not prescribe you testosterone. Typically, prescription testosterone is only given if a patient is diagnosed with lower than normal levels of testosterone, along with symptoms of low testosterone, including fatigue, decreased libido, mood changes, muscle wasting, and more.
Other patients may have low testosterone levels, but their physical health does not support their use of prescribed testosterone. For people with prostate cancer, breast cancer, serious heart disease, liver disease, or uncontrolled sleep apnea, prescription testosterone is risky, cannot be used, or requires special precautions to use prescription testosterone.
A natural decrease in testosterone levels, such as that commonly seen with age, is in most cases not enough to affect the health of the body to obtain a testosterone prescription. However, in this case, sub-health will always exist, you may appear fat, tired, muscle mass can not maintain the situation. If bodybuilders are in this situation, it will be very difficult to gain muscle mass, i.e. gain muscle, and it will be very difficult to retain it. At the same time, there will be an increase in fat mass, and it is difficult to lose fat.
Supplementation with exogenous testosterone or AAS is the most direct way to improve these symptoms, however, it is difficult to get prescription testosterone from your doctor. Some people buy testosterone or AAS from other sources, however, these sources are usually unregulated, and you can't guarantee that what you're buying is genuine. -
DHEA: Understanding its Role and Conversion to Testosterone
Many people think that using DHEA can replace the effects of testosterone, right?Dehydroepiandrosterone (DHEA) is a hormone that occurs naturally in the body and is produced primarily by the adrenal glands. It is a precursor to several other hormones, including testosterone. The conversion of DHEA to testosterone is a key process that affects various physiological functions in both men and women. Many people think that using DHEA can replace the effects of testosterone, right?
What is DHEA?
Dhea is classified as a steroid hormone and is the most abundant hormone in the human body. It plays an important role in many physiological processes, including metabolism, immune function, and sexual health. Although DHEA is produced primarily by the adrenal glands, it is also synthesized in the brain, ovaries, and testes.
Once synthesized, dehydroandrosterone circulates in the blood in an inactive form called dehydroepiandrosterone sulfate (DHEAS). It is then converted back to its active form, DHEA, by the action of the enzyme sulfase. This conversion occurs primarily in the target tissues of DHEA, such as the gonads and brain.
How is DHEA converted to testosterone?
One important way in which DHEA functions is through its conversion to testosterone. Testosterone is an important hormone for both men and women, affecting aspects of sexual development, muscle growth, and bone density. With the help of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSDS), the conversion of DHEA to testosterone occurs primarily in the gonads.
The conversion of DHEA to testosterone requires a series of enzymatic reactions. First, DHEA is converted to androstenedione by the action of 3β-hydroxysteroid dehydrogenase (3β-HSD). Androstenedione is a weak androgen that can be further converted into testosterone.
The final step in the conversion process is facilitated by the enzyme 17β-HSD, which converts androstenedione into testosterone. This step is essential for maintaining proper testosterone levels in the body
use DHEA is better than use testosterone directly?
In contrast to direct testosterone supplementation, which may inhibit endogenous testosterone secretion, DHEA, as a precursor of testosterone, indirectly increases testosterone levels. It sounds like using DHEA is better than using testosterone directly, but is it?
DHEA is a natural precursor hormone produced by the human body, and the use of DHEA can support a natural increase in testosterone levels rather than directly introducing exogenous testosterone. It should be relatively safer. However, as the article wrote earlier, the conversion of DHEA to testosterone occurs through an enzymatic reaction. In practice, this conversion is affected by many factors and is not 100% effective. The body regulates its own hormone levels and does not allow any one hormone to increase indefinitely. Therefore, excess DHEA may not lead to a proportional increa... -
Exploring FDA-Approved Testosterone Injections: A Comprehensive Review
There are three FDA-approved testosterone formulations for use: TC (Test Cypionate),TE (Test Enanthate), and TU (Test undecanoate).There are three FDA-approved testosterone formulations for use: TC (Test Cypionate),TE (Test Enanthate), and TU (Test undecanoate). They are both testosterone and have different half-lives because they are attached to ester chains of different lengths. TU has the longest ester chain, consisting of 11 carbon atoms, so it has the longest half-life and lasts longer after injection. TC and TE are composed of 7 and 8 carbon atoms, respectively.
This article provides an in-depth overview of the FDA-approved testosterone injection options, their benefits, and considerations for individuals.
TC
TC finished steroid is one of the most commonly used testosterone injections. This is a long-acting preparation that delivers testosterone slowly into the bloodstream. This reduces the frequency of injections, which are usually given every 1-2 weeks. Effective results have been shown in increasing testosterone levels and addressing symptoms associated with low testosterone.
TC is generally available in two different concentrations, 100mg/ml and 200mg/ml, dissolved in cottonseed oil.
The clinically recommended dose for testosterone therapy is 75mg-100mg intramuscular injection weekly or 150-200mg intramuscular injection every two weeks. One study of TC 200mg administration in hypogonadal males,
TE
TE is another FDA-approved testosterone injection. It is similar to TC in terms of duration of action and frequency of administration.
The common concentration of TE is 200mg/ml and is formulated with sesame oil.
TU
TU is a unique testosterone injection formulation that utilizes long-acting esters, which are used less frequently than TC and TE, and this long-acting testosterone provides convenience for those who do not prefer frequent injections.
TU is formulated with a concentration of 250mg/ml and is prepared from refined castor oil. The recommended dose is 750Mg intramuscularly every 4 weeks and, after 8 weeks, 750mg every 10 weeks.
Choose the right testosterone Injection
TC, TE and TU are three types of testosterone injection, each with its own unique characteristics and frequency of administration, users can choose their own testosterone Injection based on personal factors, lifestyle, medical history and preferences.
In addition to treating hypogonadism, these testosterone injections can increase energy levels, improve sexual function, increase muscle mass, and improve mood and health. However, possible side effects should also be considered during use, including acne, fluid retention, and potential effects on prostate health. Timely guidance from healthcare providers is essential to ensure the safe use of testosterone injection. -
Testosterone's Dual Power: Unraveling its Role in Muscle Growth and Fat Reduction
If you ask how testosterone works, most people probably don't know. Today, we will take a brief look at it.If we don't know exactly what testosterone does, we can easily name a few. If you ask how testosterone works, most people probably don't know. Today, we will take a brief look at it.
What's the use of that, you might say? Who knows, maybe one day you'll need it, maybe someone just needs the knowledge.
The action of testosterone is through a combination of many different pathways, at the cellular and organ level, the action of testosterone does not depend on genomic mechanisms, most of the action is through the binding of hormone receptors. Bound androgen receptors act as transcriptional regulatory elements by binding to specific DNA response elements in target gene promoters, causing activation or inhibition of transcription and subsequent protein synthesis.
Effects on muscle mass and strength
The effects of testosterone on muscle mass and strength occur primarily through binding to androgen receptors. The degree to which it works is positively correlated with the dose used, and if the dose used is too low, it may not have any effect.
A study giving testosterone enanthate 200mg every 2 weeks found that an increase in mass was observed after 12 weeks, with the greatest effect achieved after 6-12 months. This is a very small dose at which improvements in muscle mass and strength are observed.
Effect on bone mineral density
The effect of testosterone on bone mineral density is mediated by estrogen, which acts on testosterone derivatives produced after the interaction of testosterone with aromatase.
In the study, testosterone continued to improve lumbar bone mineral density from 6 months to 36 months.
Effect on lipids
Testosterone plays an important role in obesity, glucose homeostasis and lipid metabolism. It promotes myogenic differentiation of mesenchymal pluripotent cells through androgen receptor-mediated pathway and inhibits their differentiation into fat. After using testosterone, fat mass will decrease and lean body mass will increase. There is no significant change in total weight at the beginning, and in general, total mass begins to increase after 3 months.
Testosterone induces changes in lipid metabolism and changes in insulin signaling after the receptors in the muscles as well as an increase in insulin sensitivity, resulting in a decrease in total cholesterol levels and triglyceride levels.
Testosterone treatment also has a variety of effects such as lowering blood pressure, promoting cardiovascular health, reducing inflammation, and promoting sexual desire, affecting many parts of the body as well as physical and mental health. -
How does the thyroid hormone Triiodothyronine T3 prevent muscle loss in Cutting?
When bodybuilders use Triiodothyronine T3, it is usually used during the cutting phase, which increases the basal metabolism,When bodybuilders use Triiodothyronine T3, it is usually used during the cutting phase, which increases the basal metabolism, reduces fat and prevents muscle loss. Previously, T3 increased the basal metabolism and reduced fat, and today we will focus on how it can prevent muscle loss.
In the cutting stage, it is mainly necessary to lose the fat stored during weight gain, obtain a more linear muscle appearance, and retain as much muscle as possible in this process to prevent the loss of muscle. Triiodothyronine T3 just happens to reduce fat and prevent muscle loss.
In the process of Cutting, bodybuilders need to control their diet while increasing their exercise. In this process, the energy intake is often less than the energy consumed during exercise, leaving the body in a hungry and low energy state. During this process, the body preferentially breaks down muscles for energy.
At the same time, in the previous article about rT3, we know that the amount of rT3 produced by the body increases when the body is hungry or in a low energy state. rT3 further lowers the body's basal metabolism and begins to conserve fat. At the same time, rT3 competes with T3 for receptors, making T3 ineffective.
This is very bad for fat loss and muscle preservation in the cutting stage.
Skeletal muscle is a direct target of the thyroid hormone Triiodothyronine T3, which regulates stem cell proliferation and differentiation, and muscle fiber metabolism. In the experiment, T3 to prevent hunger mediated metabolic changes, offset the hunger caused by muscle loss, which retained the muscle quality.
Instead of preventing muscle loss by simply increasing anabolism, and without altering normal protease-mediated catabolism, T3 directly regulates muscle metabolism to counteract muscle loss.
How to prevent muscle loss in the Cutting stage or PCT stage is a very important problem, which is to some extent more difficult than acquiring muscle. The perfect muscle that Bodybuilders pursue is definitely not that bloated look, and cutting is a very important lesson for bodybuilders. Losing fat and preventing muscle loss during the cutting phase, Triiodothyronine T3 does it. -
Unveiling the Truth: Can Exogenous Testosterone Truly Replicate Natural Testosterone's Effects?
Natural testosterone refers to the testosterone naturally secreted by the body, which is mainly produced by the testicles and is regulated by positive and negative feedback of HPTA.Natural testosterone refers to the testosterone naturally secreted by the body, which is mainly produced by the testicles and is regulated by positive and negative feedback of HPTA.
Exogenous testosterone refers to testosterone introduced into the body from the outside, including testosterone replacement therapy (TRT) or anabolic steroids (AAS).
Exogenous testosterone plays a role similar to natural testosterone, but it does not completely replace the role of natural testosterone.
When exogenous testosterone is introduced, it can increase overall testosterone levels, which brings various benefits such as improving the body's anabolism, increasing muscle mass, strength, and improved athletic performance. It can also relieve symptoms associated with low testosterone, such as fatigue, decreased libido, and mood changes.
However, exogenous testosterone does not fully replicate the complex hormone levels and regulation provided by naturally produced testosterone in the body. The body's naturally produced testosterone is subject to complex feedback loops and hormonal interactions that cannot be replicated by external testosterone management alone.
Exogenous Testosterone vs Natural Testosterone
Natural testosterone is continuously secreted into the circulatory system by testicular endocrine cells, and the concentration fluctuates little, showing a circadian rhythm. Exogenous testosterone is released by a one-time injection or orally, which can cause significant fluctuations in serum testosterone levels. Because of the different ways in which they are released, the ways in which exogenous testosterone and its metabolites bind to testosterone receptors also differ.
Natural testosterone interacts with aromatase or 5AR in the body to produce testosterone metabolites, and corresponding actions also occur in the body. Some exogenous testosterone is derived from testosterone, but the structure will change, and when it does not interact with aromatase or 5AR, it will also bring corresponding side effects.
Exogenous testosterone levels are not controlled by the endocrine system, and excessive use or absence of medical supervision during use can cause side effects including hormonal imbalance, cardiovascular, mood, and inhibition of natural testosterone production. -
Testosterone forms when using for medical
Since its discovery and in-depth study by biologists, testosterone has provided many new directions for human health and disease treatment. When testosterone is used for medical purposes, it usually cSince its discovery and in-depth study by biologists, testosterone has provided many new directions for human health and disease treatment. When testosterone is used for medical purposes, it usually comes in the form of exogenous testosterone, which is used to supplement or replace the body's naturally produced testosterone and has an irreplaceable role. There are various forms of medical testosterone available, and This blog will begin with a few forms when using testosterone for medical purposes.
Take orally
Oral testosterone is easy to use, but it is metabolized by the liver and has low bioavailability, so oral testosterone is not widely used. The orally available testosterone is testosterone undecanoate (TU). The alkylation of testosterone on C17α produces testosterone derivatives with the ability to bypass first-pass metabolism, but with certain hepatotoxicity, such as methyltestosterone
Injection
Intramuscular injections are the most common form of testosterone use. Common ones are to test cypionate and test enanthate, which allow for the slow release of testosterone into the bloodstream, providing stable testosterone levels for 1-4 weeks.
Topical gels and creams
These include 1% and 2% testosterone gels applied daily to the skin and absorbed through the bloodstream. The testosterone levels they provide are fluctuating, but they are more convenient to use and provide a convenient option for testosterone supplementation.
Testosterone patch
These drug patches are placed on the skin and deliver a certain amount of testosterone into the bloodstream. They are usually attached to the arms or upper body and sustainably release testosterone. Change every 24-72 hours depending on the specific patch.
Testosterone pellets
During minor surgery, subcutaneous pellets are surgically implanted. This small pill slowly releases testosterone over a period of 3-6 months, providing long-lasting effects. It was the first effective formulation developed in the 1940s.
Testosterone in the oral system
Oral dosing was originally approved by the FDA in 2003. This use delivers testosterone directly to the systemic circulation and bypasses the liver, avoiding first-pass metabolism and improving bioavailability.
This involves placing a testosterone tablet between the cheek and gums and slowly releasing testosterone into the body. It needs to be changed twice a day.
Low testosterone levels are associated with a shorter life span and an increased risk of many diseases, as well as sexual dysfunction, muscle and bone degradation, out-of-shape shape, metabolic disorders, and decreased immunity, endangering physical and mental health. Fortunately, with the development of science and technology, and the in-depth study of testosterone and its derivatives, the phenomenon of low testosterone can be well s... -
Relationship of testosterone ester chain length to half-life and solubility
The half-life of testosterone is very short, only a few hours, and the testosterone after the addition of ester has a longer half-life, avoiding the trouble of frequent administration.When understanding the half-life of a testosterone derivative, we will propose that its half-life is related to the length of the ester to which it is linked, and the longer the length of the ester chain, the longer the half-life of the corresponding compound. The half-life of testosterone is very short, only a few hours, and the testosterone after the addition of ester has a longer half-life, avoiding the trouble of frequent administration.
The half-life of various testosterone esters
Test Acetate, C21H30O3, half-life for 3 days,
Test Propionate, C22H32O3, half-life 4.5 days,
Test Phenylpropionate, C28H36O3, half-life 4.5 days,
Test Isocaproate, C25H38O3, half-life, 9 days
Test Enanthate, C26H40O3, half-life 10.5 days
Test Cypionate, C27H40O3, half-life 12 days
Test Decanoate, C29H46O3, half-life for 15 days
Test undecanoate, C30H48O3, half-life 16.5 days
Extending the half-life is of great significance, so does the length of the ester chain only prolong the half-life?
It's not just that. The length of the attached ester chain also affects the solubility of the compound. Testosterone esters are essentially injected, and increased solubility increases the amount of active compounds contained in the per ml solution.
By testosterone acetate (TAce), testosterone propionate (TPro), testosterone phenylpropionate (TPhp), Experimentation with the solubility of testosterone isocaproate (TIso) has observed that the solubility is correlated with the half-life of the prodrug, so that the acetate with the shortest half-life has the lowest solubility and the isocaproate with the longest half-life has the highest solubility. The longest ester (isocaproate) is about four times more soluble.
In the experiment, although the phenylpropionate has six more carbon atoms than the propionate, the solubility is similar, so it can be noted that the important factor that increases the solubility is the length of the carbon chain, and the benzene ring does not lead to an increase in solubility.
The longer the ester chain, the higher the solubility of testosterone ester, and the higher the solubility is conducive to improving the content of active ingredients in the finished solution, which is conducive to the stability of the solution, convenient for drug administration, and also to the further preparation of the follow-up.
In experiments, of the six liquids used to dissolve testosterone esters, it was observed that castor oil could support the highest solubility without collapse (compound crystallization) and to a lesser extent MCT (for TAce, TPro, and TPhp), while also acting as a solvent. This is interesting because MCT is characterized by the lowest viscosity coefficient, while castor oil has the highest viscosity.
Therefore, the reasonable selection of testosterone ester and the cor... -
Chemical structure and function of testosterone
Testosterone is a steroid compound with a typical sterane core structure consisting of three carbon five-membered rings and one carbon four-membered ring. It has the formula C19H28O2 and belongs toTestosterone is a naturally occurring male sex hormone in the human body. It is produced mainly in the testicles of men and in small amounts in the ovaries and adrenal glands of women. Testosterone is a steroid compound with a typical sterane core structure consisting of three carbon five-membered rings and one carbon four-membered ring. It has the formula C19H28O2 and belongs to the androstane family, specifically the 17-β-hydroxy-androstane-3-1 family.
The main chemical characteristics of testosterone
1. Two hydroxyl groups in the C-19 position. Through these two hydroxyl groups, testosterone can bind to testosterone receptors and exert biological activity.
2. A hydroxyl group at the C-17 position. By migrating the hydroxyl group, the effect of estrogen is generated.
3. Seven carbon-carbon double bonds. These carbon-carbon double bonds give the molecule a planar structure that facilitates binding to testosterone receptors.
The structure of testosterone determines its biological function
1. After binding to testosterone receptors, it activates related signal transduction pathways, promotes muscle protein synthesis, increases muscle size and strength, helps maintain bone density and prevent osteoporosis. At the same time, it regulates secondary sexual characteristics, such as stimulating sperm production, affecting sexual desire and sexual function.
2. The hydroxyl group of C-17 is easily reduced to a keto group, producing dihydrotestosterone (DHT), which has a higher affinity and can more effectively promote the development of secondary sexual characteristics and maintain sexual function.
3. Testosterone can be converted into estrogen through the displacement reaction and the removal of hydroxyl groups, which has the role of regulating secondary sex characteristics and promoting bone health.
4. Testosterone has a typical sterol structure, which is conducive to its passage through biofilms. And can bind SHBG and other binding proteins, convenient transport in the blood, play a role in various parts of the body.
5. Variations in the structure of testosterone can produce different derivatives or analogues with different biological effects and pharmacokinetic properties, playing a huge medical role.
In summary, the chemical structure of testosterone determines its multiple biological effects. From the chemical structure, we can know what role it may have. Through the study of its chemical structure, biologists can find and synthesize a variety of testosterone derivatives, which play different roles in different fields and provide new treatments for health and disease.
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